Purdy’s Perfection: 49ers Dominate Indy on MNF

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Last night’s Week 16 edition of Monday Night Football saw a masterclass in efficiency from the San Francisco 49ers as they dismantled the Indianapolis Colts in a high-scoring primetime affair.

Scoreboard: Monday, December 22, 2025

Away Team	Score	Home Team	Score	Top Performer
S.F. 49ers	48	Indianapolis Colts	27	B. Purdy (295 YDS, 5 TD)

Top Headlines & Storylines

1. Brock Purdy Makes History

Brock Purdy turned in the most prolific performance of his young career, throwing a career-high 5 touchdown passes. He became the first quarterback in 49ers history to throw 5 touchdowns on Monday Night Football, tying the franchise single-game record. Purdy was surgical, completing 25-of-34 passes and leading scoring drives in every single quarter.

2. McCaffrey’s Milestone Night

Christian McCaffrey proved once again why he is the engine of the Niners’ offense. With 117 rushing yards, he officially surpassed the 1,000-yard rushing mark for the season. He also added two receiving touchdowns, making him just the fifth player in NFL history to record 1,800+ yards from scrimmage in five different seasons.

3. The Ripple Effect: Playoff Berths Clinched

While the 49ers had already secured their playoff ticket thanks to a Lions loss on Sunday, their victory last night sent shockwaves through the AFC. Because the Colts lost:

The Jacksonville Jaguars officially clinched an AFC playoff spot.
The Buffalo Bills officially punched their ticket to the postseason for the seventh straight year.
The Colts saw their playoff hopes effectively evaporate, moving to 8-7 with a tough road ahead.

4. The “Old Man” Rivers Effort

44-year-old Philip Rivers continued his improbable comeback season with a gritty performance. He threw for 277 yards and 2 touchdowns, keeping Indy within one score early in the fourth quarter. However, a late-game 74-yard pick-six by Dee Winters put the game out of reach and served as a somber exclamation point on a night where the Colts’ defense simply couldn’t get a stop.